Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development

  • Stefan Holiga
  • Ahmed Abdulkadir
  • Stefan Klöppel
  • Juergen Dukart
Part of the Methods in Molecular Biology book series (MIMB, volume 1750)


While now commonly applied for studying human brain function the value of functional magnetic resonance imaging in drug development has only recently been recognized. Here we describe the different functional magnetic resonance imaging techniques applied in Alzheimer’s disease drug development with their applications, implementation guidelines, and potential pitfalls.

Key words

fMRI Alzheimer’s disease Treatment Prevention Biomarker Dementia 


  1. 1.
    Kapur S, Zipursky RB, Remington G et al (1998) 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry 155(7):921–928. CrossRefPubMedGoogle Scholar
  2. 2.
    Nordstrom AL, Farde L, Wiesel FA et al (1993) Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol Psychiatry 33(4):227–235CrossRefPubMedGoogle Scholar
  3. 3.
    Borsook D, Becerra L, Hargreaves R (2006) A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov 5(5):411–424. CrossRefPubMedGoogle Scholar
  4. 4.
    Logothetis NK (2008) What we can do and what we cannot do with fMRI. Nature 453(7197):869–878. CrossRefPubMedGoogle Scholar
  5. 5.
    Okon-Singer H, Mehnert J, Hoyer J et al (2014) Neural control of vascular reactions: impact of emotion and attention. J Neurosci 34(12):4251–4259. CrossRefPubMedGoogle Scholar
  6. 6.
    Van Dijk KR, Sabuncu MR, Buckner RL (2012) The influence of head motion on intrinsic functional connectivity MRI. NeuroImage 59(1):431–438. CrossRefPubMedGoogle Scholar
  7. 7.
    Volkow ND, Wang GJ, Fowler JS et al (2003) Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma. Psychopharmacology (Berl) 166(3):264–270. CrossRefGoogle Scholar
  8. 8.
    Fusar-Poli P, Smieskova R, Kempton MJ et al (2013) Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev 37(8):1680–1691. CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Stefan Holiga
    • 1
  • Ahmed Abdulkadir
    • 2
  • Stefan Klöppel
    • 2
  • Juergen Dukart
    • 1
    • 3
  1. 1.F. Hoffmann-La Roche, pharma Research Early DevelopmentRoche Innovation Centre BaselBaselSwitzerland
  2. 2.University Hospital of Old Age Psychiatry and Psychotherapy BernBernSwitzerland
  3. 3.Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Discovery and Translational AreaRoche Innovation Center BaselBaselSwitzerland

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