In Vivo Models for Inflammatory Arthritis

  • Gareth W. JonesEmail author
  • David G. Hill
  • Katie Sime
  • Anwen S. Williams
Part of the Methods in Molecular Biology book series (MIMB, volume 1725)


In vivo mouse models of inflammatory arthritis are extensively used to investigate pathogenic mechanisms governing inflammation-driven joint damage. Two commonly utilized models include collagen-induced arthritis (CIA) and methylated bovine serum albumin (mBSA) antigen-induced arthritis (AIA). These offer unique advantages for modeling different aspects of human disease. CIA involves breach of immunological tolerance resulting in systemic autoantibody-driven arthritis, while AIA results in local resolving inflammatory flares and articular T cell-mediated damage. Despite limitations that apply to all animal models of human disease, CIA and AIA have been instrumental in identifying pathogenic mediators, immune cell subsets and stromal cell responses that determine disease onset, progression, and severity. Moreover, these models have enabled investigation of disease phases not easily studied in patients and have served as testing beds for novel biological therapies, including cytokine blockers and small molecule inhibitors of intracellular signaling that have revolutionized rheumatoid arthritis treatment.

Key words

Inflammatory arthritis Rheumatoid arthritis Collagen-induced arthritis Antigen-induced arthritis Histopathology 



G.J. is supported by an Arthritis Research UK Career Development Fellowship (20305). D.H. is supported by a Medical Research Council PhD studentship and Life Science Research Network Wales, an initiative funded through the Welsh Government’s Ser Cymru program. K.S. is supported by a PhD studentship funded through a generous donation from The Elizabeth Owens Bequest at Cardiff University.


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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Gareth W. Jones
    • 1
    Email author
  • David G. Hill
    • 1
  • Katie Sime
    • 1
  • Anwen S. Williams
    • 1
  1. 1.Division of Infection and Immunity, Systems Immunity University Research Institute, School of MedicineCardiff UniversityCardiffUK

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