Dynamic Contrast-Enhanced MRI

  • Jennifer Moroz
  • Stefan A. Reinsberg
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1718)

Abstract

Dynamic contrast-enhanced MRI in pre-clinical imaging allows the in-vivo monitoring of vascular, physiological properties in normal and diseased tissue. There is considerable variation in the methods employed owing to the different questions that can be asked and answered about the physiologic alterations as well as morphologic changes in tissue. Here we review the typical decisions in the design and execution of a dynamic contrast-enhanced MRI study in mice although the findings can easily be transferred to other species. Emphasis is placed on highlighting the many pitfalls that wait for the unaware pre-clinical MRI practitioner and that go often unmentioned in the abundant literature dealing with dynamic contrast-enhanced MRI in animal models.

Key words

Pharmacodynamics Gadolinium chelate Blood flow Vessel permeability Ktrans IAUC60 

Notes

Acknowledgements

This work was made possible through support from the Discovery Program of NSERC and CIHR.

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Copyright information

© Springer Science+Business Media, LLC 2018

Authors and Affiliations

  • Jennifer Moroz
    • 1
  • Stefan A. Reinsberg
    • 1
  1. 1.Department of Physics and AstronomyThe University of British ColumbiaVancouverCanada

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