Extended Metabolic Space Modeling
Determining the fraction of the chemical space that can be processed in vivo by using natural and synthetic biology devices is crucial for the development of advanced synthetic biology applications. The extended metabolic space is a coding system based on molecular signatures that enables the derivation of reaction rules for metabolic reactions and the enumeration of all possible substrates and products corresponding to the rules. The extended metabolic space expands capabilities for controlling the production, processing, sensing, and the release of specific molecules in chassis organisms.
Key wordsMetabolic modeling Enzyme reactions Pathways Products Chassis
The authors acknowledge funding from the BBSRC under grant BB/M017702/1, “Centre for synthetic biology of fine and speciality chemicals.” J.L.F. acknowledges funding provided by the ANR under grant ANR-15-CE21-008. B.D. is affiliated to the Doctoral School Structure et Dynamique des Systèmes Vivant, Université Paris-Saclay.
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