ErbB Receptor Signaling pp 127-133 | Cite as
Two-Pulse Endosomal Stimulation of Receptor Tyrosine Kinases Induces Cell Proliferation
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Abstract
Signals transduced from ligand-activated receptor tyrosine kinases (RTKs) lead to a diverse array of biological outcomes, such as cell proliferation. Strict regulation of RTK activity is therefore necessary to prevent aberrancies in cell signaling that can lead to diseases such as cancer. RTKs are activated at the plasma membrane (PM) upon ligand binding. Contrary to the initial belief, RTK activity does not terminate immediately following endocytosis, instead RTKs remain active while being trafficked in endosomes. Here we describe a two-pulse endosomal stimulation approach which can specifically activate endosome-accumulated EGFR and drive cell proliferation.
Key words
Endosome Epidermal growth factor receptor (EGFR) Receptor tyrosine kinase (RTK) Two pulse Cell proliferationReferences
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