Two-Pulse Endosomal Stimulation of Receptor Tyrosine Kinases Induces Cell Proliferation

  • Steven Pennock
  • Sukhmani Billing
  • Zhixiang Wang
  • Yi Wang
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1652)

Abstract

Signals transduced from ligand-activated receptor tyrosine kinases (RTKs) lead to a diverse array of biological outcomes, such as cell proliferation. Strict regulation of RTK activity is therefore necessary to prevent aberrancies in cell signaling that can lead to diseases such as cancer. RTKs are activated at the plasma membrane (PM) upon ligand binding. Contrary to the initial belief, RTK activity does not terminate immediately following endocytosis, instead RTKs remain active while being trafficked in endosomes. Here we describe a two-pulse endosomal stimulation approach which can specifically activate endosome-accumulated EGFR and drive cell proliferation.

Key words

Endosome Epidermal growth factor receptor (EGFR) Receptor tyrosine kinase (RTK) Two pulse Cell proliferation 

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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Steven Pennock
    • 1
    • 4
  • Sukhmani Billing
    • 2
  • Zhixiang Wang
    • 1
  • Yi Wang
    • 1
    • 3
  1. 1.Signal Transduction Research Group, Department of Medical Genetics, Faculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada
  2. 2.Department of BiochemistryMcMaster UniversityHamiltonCanada
  3. 3.Canadian Nuclear LaboratoriesChalk RiverCanada
  4. 4.Regeneron Pharmaceuticals Inc.TarrytownUSA

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