Chitosan Nanoparticles for miRNA Delivery
RNA interference techniques represent a promising strategy for therapeutic applications. In addition to small interfering RNA-based approaches, which have been widely studied and translated into clinical investigations, microRNA-based approaches are attractive owing to their “one hit, multiple targets” concept. To overcome challenges with in vivo delivery of microRNAs related to stability, cellular uptake, and specific delivery, our group has developed and characterized chitosan nanoparticles for nucleotide delivery. This platform allows for robust target modulation and antitumor activity following intravenous administration.
Key wordsRNA interference miR-34a microRNA delivery Chitosan nanoparticles Prostate cancer
Portions of this work were supported by the NIH (CA016672, CA109298, P50 CA083639, P50 CA098258, UH3 TR000943), the Ovarian Cancer Research Fund, Inc. (Program Project Development Grant), the Blanton-Davis Ovarian Cancer Research Program, the RGK Foundation, and the Gilder Foundation.
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