Mycobacterial Load Assay
Tuberculosis is a difficult disease to treat, a process made more harder as tools to monitor treatment response only provide a result long after the patient has provided a sample. The mycobacterial load assay (MBLA) provides a simple molecular test to quantify and determine the viability of M. tuberculosis in human or other samples.
Key wordsMycobacterial load assay (MBLA) Sputum Ribosomal RNA (rRNA) Reverse transcriptase real-time quantitative polymerase chain reaction (RT-qPCR)
- 3.Bowness R, Boeree MJ, Aarnoutse R et al (2014) The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations. J Antimicrob Chemother 70(2):448–455. doi: 10.1093/jac/dku415 CrossRefPubMedGoogle Scholar