Th9 Cells pp 223-245

Part of the Methods in Molecular Biology book series (MIMB, volume 1585) | Cite as

Th9 Cells and Parasitic Inflammation: Use of Nippostrongylus and Schistosoma Models

  • Miguel Enrique Serrano Pinto
  • Paula Licona-Limón


Th9 cells are a new subpopulation of CD4+ T helper cells, characterized by the expression of IL-9 that have been involved in type 2 immune responses, antitumor responses and autoimmune diseases. Here, we describe two different parasitic models frequently maintained in the laboratory where Th9 cells or IL-9 (the cytokine produced by Th9 cells) has been shown to play critical roles in pathogen clearance and immune response activation: the nematode Nippostrongylus brasiliensis and the trematode Schistosoma mansoni.

Key words

IL-9 Type 2 immune response Helminth Th9 Parasite infection 


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Copyright information

© Springer Science+Business Media LLC 2017

Authors and Affiliations

  • Miguel Enrique Serrano Pinto
    • 1
  • Paula Licona-Limón
    • 1
  1. 1.Departamento de Biología Celular y del DesarrolloInstituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoMexico CityMexico

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