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Liposomes pp 257–272Cite as

Targeted Magnetic Liposomes Loaded with Doxorubicin

Part of the Methods in Molecular Biology book series (MIMB,volume 1522)

Abstract

Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor-targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.

Key words

  • Targeted
  • Magnetic nanoparticles
  • Magnetic liposomes
  • Folate
  • Doxorubicin

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  • DOI: 10.1007/978-1-4939-6591-5_21
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Acknowledgements

Financial support of the German Excellence Initiative via the “Nanosystems Initiative Munich (NIM)” is gratefully acknowledged. Pallab Pradhan gratefully acknowledges DAAD (Deutscher Akademischer Austausch Dienst) for awarding the “DAAD Sandwich fellowship” for pursuing the research in Germany. Support from DST, Govt. of India is also gratefully acknowledged.

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Correspondence to Pallab Pradhan .

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Pradhan, P., Banerjee, R., Bahadur, D., Koch, C., Mykhaylyk, O., Plank, C. (2017). Targeted Magnetic Liposomes Loaded with Doxorubicin. In: D'Souza, G. (eds) Liposomes. Methods in Molecular Biology, vol 1522. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6591-5_21

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  • DOI: https://doi.org/10.1007/978-1-4939-6591-5_21

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  • Publisher Name: Humana Press, New York, NY

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