Microencapsulation in Clinical Islet Xenotransplantation
Allogeneic islet transplantation has become a viable treatment for patients with unstable type 1 diabetes; however, donor shortage and the necessity for immunosuppressive drugs are the major drawbacks of this approach. Microencapsulated porcine islet xenotransplantation could solve these drawbacks. Clinical porcine islet xenotransplantation as well as microencapsulated islet transplantation has been conducted without significant side effects. However, these transplantations are not as efficacious as allogeneic naked islet transplantation. High quality porcine islets, biocompatible capsules, and appropriate implant sites should be the key factors for improving efficacy. With improved efficacy, microencapsulated islet xenotransplantation will solve the major drawbacks associated with current islet transplantation.
Key wordsPorcine islet Encapsulation Alginate APA capsule Xenotransplantation
- 7.Wang W, Mo Z, Ye B et al (2011) A clinical trial of xenotransplantation of neonatal pig islets for diabetic patients. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:1134–1140Google Scholar
- 20.Noguchi H, Levy MF, Kobayashi N, Matsumoto S (2009) Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution? Cell Transplant 18:497–503Google Scholar
- 24.Ricordi C, Socci C, Davalli AM et al (1990) Isolation of the elusive pig islet. Surgery 107:688–694Google Scholar