Injury Models of the Central Nervous System

Volume 1462 of the series Methods in Molecular Biology pp 177-192


The Controlled Cortical Impact Model of Experimental Brain Trauma: Overview, Research Applications, and Protocol

  • Nicole OsierAffiliated withSafar Center for Resuscitation Research, University of PittsburghSchool of Nursing, University of Pittsburgh
  • , C. Edward DixonAffiliated withSafar Center for Resuscitation Research, University of PittsburghDepartment of Neurological Surgery, University of PittsburghV.A. Pittsburgh Healthcare System Email author 

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Controlled cortical impact (CCI) is a commonly used and highly regarded model of brain trauma that uses a pneumatically or electromagnetically controlled piston to induce reproducible and well-controlled injury. The CCI model was originally used in ferrets and it has since been scaled for use in many other species. This chapter will describe the historical development of the CCI model, compare and contrast the pneumatic and electromagnetic models, and summarize key short- and long-term consequences of TBI that have been gleaned using this model. In accordance with the recent efforts to promote high-quality evidence through the reporting of common data elements (CDEs), relevant study details—that should be reported in CCI studies—will be noted.

Key words

Traumatic brain injury (TBI) Experimental brain injury Preclinical Animal model Controlled cortical impact (CCI) Common data elements (CDE)