Experimental Models of Anxiety for Drug Discovery and Brain Research

  • Peter C. Hart
  • Carisa L. Bergner
  • Amanda N. Smolinsky
  • Brett D. Dufour
  • Rupert J. Egan
  • Justin L. LaPorte
  • Allan V. Kalueff
Part of the Methods in Molecular Biology book series (MIMB, volume 1438)

Abstract

Animal models have been vital to recent advances in experimental neuroscience, including the modeling of common human brain disorders such as anxiety, depression, and schizophrenia. As mice express robust anxiety-like behaviors when exposed to stressors (e.g., novelty, bright light, or social confrontation), these phenotypes have clear utility in testing the effects of psychotropic drugs. Of specific interest is the extent to which mouse models can be used for the screening of new anxiolytic drugs and verification of their possible applications in humans. To address this problem, the present chapter will review different experimental models of mouse anxiety and discuss their utility for testing anxiolytic and anxiogenic drugs. Detailed protocols will be provided for these paradigms, and possible confounds will be addressed accordingly.

Key words

Anxiety Experimental animal models Anxiolytic drugs Anxiogenic drugs Biological psychiatry Exploration 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Peter C. Hart
    • 1
  • Carisa L. Bergner
    • 1
  • Amanda N. Smolinsky
    • 1
  • Brett D. Dufour
    • 2
  • Rupert J. Egan
    • 1
  • Justin L. LaPorte
    • 3
  • Allan V. Kalueff
    • 1
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 9
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashington, DCUSA
  2. 2.Department of Animal SciencesPurdue UniversityWest LafayetteUSA
  3. 3.Stress Physiology and Research Center (SPaRC)Georgetown University Medical CenterWashington, DCUSA
  4. 4.Department of PharmacologyTulane University Medical CenterNew OrleansUSA
  5. 5.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashington, DCUSA
  6. 6.The International Stress and Behavior Society (ISBS) and ZENEREI Research CenterSlidellUSA
  7. 7.Research Institute of Marine Drugs and Nutrition, College of Food Science and TechnologyGuangdong OceanUniversityZhanjiangChina
  8. 8.Institute of Translational BiomedicineSt. Petersburg State UniversitySt. PetersburgRussia
  9. 9.Institutes of Chemical Technology and Natural SciencesUral Federal UniversityEkaterinburgRussia

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