Mouse Models for Studying Depression-Like States and Antidepressant Drugs

  • Carisa L. Bergner
  • Amanda N. Smolinsky
  • Peter C. Hart
  • Brett D. Dufour
  • Rupert J. Egan
  • Justin L. LaPorte
  • Allan V. KalueffEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1438)


Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice, and their utility in screening antidepressant drugs.

Key words

Depression Animal models Antidepressant drug screening Despair Anhedonia Chronic stress 



This work was supported by NARSAD YI Award to AVK, and by Stress Physiology and Research Center (SPaRC) of Georgetown University Medical School. AVK is the President of the International Stress and Behavior Society (ISBS, He is supported by Guangdong Ocean University, St. Petersburg State University (internal grant and Ural Federal University (Government of Russian Federation Act 211, contract 02-A03.21.0006).


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Carisa L. Bergner
    • 1
  • Amanda N. Smolinsky
    • 1
  • Peter C. Hart
    • 1
  • Brett D. Dufour
    • 2
  • Rupert J. Egan
    • 1
  • Justin L. LaPorte
    • 1
    • 3
  • Allan V. Kalueff
    • 1
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 9
    Email author
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashington, DCUSA
  2. 2.Department of Animal SciencesPurdue UniversityWest LafayetteUSA
  3. 3.Stress Physiology and Research Center (SPaRC)Georgetown University Medical CenterWashington, DCUSA
  4. 4.Department of PharmacologyTulane University Medical CenterNew OrleansUSA
  5. 5.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashington, DCUSA
  6. 6.Research Institute for Marine Drugs and NutritionCollege of Food Science and TechnologyZhanjiangChina
  7. 7.Institute of Translational BiomedicineSt. Petersburg State UniversitySt. PetersburgRussia
  8. 8.ZENEREI Research CenterSlidellUSA
  9. 9.Chemicotechnological Institute Ural Federal State University EkaterinburgRussia

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