Mouse Models for Studying Depression-Like States and Antidepressant Drugs
Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice, and their utility in screening antidepressant drugs.
Key wordsDepression Animal models Antidepressant drug screening Despair Anhedonia Chronic stress
This work was supported by NARSAD YI Award to AVK, and by Stress Physiology and Research Center (SPaRC) of Georgetown University Medical School. AVK is the President of the International Stress and Behavior Society (ISBS, www.stressandbehavior.com). He is supported by Guangdong Ocean University, St. Petersburg State University (internal grant 188.8.131.524) and Ural Federal University (Government of Russian Federation Act 211, contract 02-A03.21.0006).
- 10.Geyer MA, Markou A (1995) Animal models of psychiatric disorders. In: Kupfer DJ, Bloom F (eds) Psychopharmacology the fourth generation of progress. Raven Press, New York, pp 787–798Google Scholar
- 15.Jackson-Laboratory (2008) Mouse genome informatics. http://www.informatics.jax.org/
- 19.Kos T, Legutko B, Danysz W, Samoriski G, Popik P (2006) Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice. J Pharmacol Exp Ther 318:1128–1136. Google Scholar
- 26.Zhao Z, Wang W, Guo H, Zhou D (2008) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res 194:108–113.Google Scholar
- 49.Rauskolb S (2008) Brain-derived neurotrophic factor: generation and characterization of adult mice lacking BDNF in the adult brain, p 91. University of Basel, Basel, GermanyGoogle Scholar