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Mouse Models for Drug Discovery

Volume 1438 of the series Methods in Molecular Biology pp 255-269

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Mouse Models for Studying Depression-Like States and Antidepressant Drugs

  • Carisa L. BergnerAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical School
  • , Amanda N. SmolinskyAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical School
  • , Peter C. HartAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical School
  • , Brett D. DufourAffiliated withDepartment of Animal Sciences, Purdue University
  • , Rupert J. EganAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical School
  • , Justin L. LaPorteAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical SchoolStress Physiology and Research Center (SPaRC), Georgetown University Medical Center
  • , Allan V. KalueffAffiliated withDepartment of Physiology and Biophysics, Georgetown University Medical SchoolStress Physiology and Research Center (SPaRC), Georgetown University Medical CenterDepartment of Pharmacology, Tulane University Medical CenterDepartment of Physiology and Biophysics, Georgetown University Medical SchoolResearch Institute for Marine Drugs and Nutrition, College of Food Science and TechnologyInstitute of Translational Biomedicine, St. Petersburg State UniversityZENEREI Research CenterChemicotechnological Institute, Ural Federal State University  Email author 

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Abstract

Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice, and their utility in screening antidepressant drugs.

Key words

Depression Animal models Antidepressant drug screening Despair Anhedonia Chronic stress