Review of Mouse and Human Dendritic Cell Subsets

  • Elodie Segura
Part of the Methods in Molecular Biology book series (MIMB, volume 1423)


Dendritic cells are specialized antigen-presenting cells that initiate and orient immune responses. Numerous studies in mice and humans have shown that dendritic cells are heterogeneous and comprise several subsets that can be distinguished by their surface phenotype, ontogeny, and molecular signature. This review gives an overview of mouse and human dendritic cell subsets and their defining features and summarizes the current knowledge of dendritic cell subsets’ functional specialization in terms of antigen presentation.

Key words

Dendritic cells Subsets Human Mouse Antigen presentation 



This work is supported by INSERM, the European Research Council, LabEx DCBiol, and Ligue contre le Cancer .


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institut CurieParis Cedex 05France
  2. 2.INSERM U932Paris Cedex 05France

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