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Vaccine Design pp 313-328 | Cite as

Alphavirus-Based Vaccines

  • Kenneth LundstromEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1404)

Abstract

Alphavirus vectors based on Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been widely applied for vaccine development. Naked RNA replicons, recombinant viral particles, and layered DNA vectors have been subjected to immunization in preclinical animal models with antigens for viral targets and tumor antigens. Moreover, a limited number of clinical trials have been conducted in humans. Vaccination with alphavirus vectors has demonstrated efficient immune responses and has showed protection against challenges with lethal doses of virus and tumor cells, respectively. Moreover, vaccines have been developed against alphaviruses causing epidemics such as Chikungunya virus.

Keywords

Alphaviruses Immunization Viral vaccines Cancer vaccines Protection 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.PanTherapeuticsLutrySwitzerland

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