Glycocalyx Remodeling with Glycopolymer-Based Proteoglycan Mimetics
The cellular glycocalyx controls many of the crucial signaling pathways involved in cellular development. Synthetic materials that can mimic the multivalency and three-dimensional architecture of native glycans serve as important tools for deciphering and exploiting the roles of these glycans. Here we describe a chemical approach for the engineering of growth-factor interactions at the surfaces of stem cells using synthetic glycomimetic materials, with an eye towards promoting their commitment towards specific cell lineages with therapeutic potential.
Key wordsGlycan microarrays Glycopolymers Glycosaminoglycans Proteoglycans Stem cells Stem cell differentiation
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