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Magnetic Resonance Imaging of the Atherosclerotic Mouse Aorta

  • Jesús MateoEmail author
  • Marina Benito
  • Samuel España
  • Javier Sanz
  • Jesús Jiménez-Borreguero
  • Valentín Fuster
  • Jesús Ruiz-Cabello
Part of the Methods in Molecular Biology book series (MIMB, volume 1339)

Abstract

Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T1, T2, and proton density). Here, we illustrate a standard procedure to image the aorta of atherosclerotic mice using noninvasive MRI.

Key words

Magnetic resonance imaging (MRI) Atherosclerosis Plaque Aorta apoE-KO mice 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jesús Mateo
    • 1
    Email author
  • Marina Benito
    • 1
    • 2
  • Samuel España
    • 1
  • Javier Sanz
    • 3
  • Jesús Jiménez-Borreguero
    • 1
    • 4
  • Valentín Fuster
    • 1
    • 3
  • Jesús Ruiz-Cabello
    • 1
    • 2
    • 5
  1. 1.Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)MadridSpain
  2. 2.CIBER de Enfermedades Respiratorias (CIBERES)MadridSpain
  3. 3.The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular HealthIcahn School of MedicineNew YorkUSA
  4. 4.Hospital Universitario de La PrincesaMadridSpain
  5. 5.Universidad Complutense de MadridMadridSpain

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