A Newborn Piglet Survival Model of Post-hemorrhagic Ventricular Dilatation (PHVD)

Part of the Neuromethods book series (NM, volume 104)

Abstract

Intra-ventricular hemorrhage (IVH) and post-hemorrhagic ventricular dilatation (PHVD) are important issues in neonatal care and continue to contribute to significant motor and cognitive morbidity. Several questions about its pathophysiology remain unanswered and animal models have been useful in identifying relevant risk factors and potential mechanisms. In this chapter, we describe a neonatal piglet model of IVH and PHVD involving the injection of homologous blood with an elevated hematocrit into the ventricular system. The animals are capable of long-term survival and, through a ventricular access device inserted in the second week, allow repeated aspiration of cerebrospinal fluid and measurement of intraventricular pressure.

Key words

Pig Newborn Neonatal intraventricular hemorrhage Post-hemorrhagic ventricular dilatation Hydrocephalus Ventricular access device Intraventricular pressure monitoring 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.School of Clinical SciencesUniversity of BristolBristolUK
  2. 2.Department of Pediatric NeurosurgeryGreat Ormond Street HospitalLondonUK
  3. 3.Division of Physiology at Institute of Basic Medical SciencesUniversity of OsloOsloNorway
  4. 4.School of Clinical Sciences, St Michaels Hospital, Child Health, Level DUniversity of BristolBristolUK

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