A Practical Guide for Exploring Opportunities of Repurposing Drugs for CNS Diseases in Systems Biology

  • Hongkang Mei
  • Gang Feng
  • Jason Zhu
  • Simon Lin
  • Yang Qiu
  • Yue Wang
  • Tian Xia
Part of the Methods in Molecular Biology book series (MIMB, volume 1303)

Abstract

Systems biology has shown its potential in facilitating pathway-focused therapy development for central nervous system (CNS) diseases. An integrated network can be utilized to explore the multiple disease mechanisms and to discover repositioning opportunities. This review covers current therapeutic gaps for CNS diseases and the role of systems biology in pharmaceutical industry. We conclude with a Multiple Level Network Modeling (MLNM) example to illustrate the great potential of systems biology for CNS diseases. The system focuses on the benefit and practical applications in pathway centric therapy and drug repositioning.

Key words

Systems biology Disease network Multiple level network modeling (MLNM) Drug repositioning Pharmacology 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Hongkang Mei
    • 1
  • Gang Feng
    • 2
  • Jason Zhu
    • 1
  • Simon Lin
    • 2
  • Yang Qiu
    • 1
  • Yue Wang
    • 3
  • Tian Xia
    • 3
  1. 1.Informatics and Structure BiologyR&D China, GlaxoSmithKlineShanghaiChina
  2. 2.Biomedical Informatics CenterNorthwestern University Clinical and Translational Sciences InstituteChicagoUSA
  3. 3.Department of Electronics and Information EngineeringHuazhong University of Science and TechnologyWuhanChina

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