Systems Biology of Alzheimer's Disease pp 423-432

Part of the Methods in Molecular Biology book series (MIMB, volume 1303) | Cite as

AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer’s Disease Pathogenesis

  • Soichi Ogishima
  • Satoshi Mizuno
  • Masataka Kikuchi
  • Akinori Miyashita
  • Ryozo Kuwano
  • Hiroshi Tanaka
  • Jun Nakaya

Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which loss of neurons and synaptic function causes dementia in the elderly. To clarify AD pathogenesis and develop drugs for AD, thousands of studies have elucidated signaling pathways involved. However, knowledge of AD signaling pathways has not been compiled as a pathway map. In this chapter, we introduce the manual construction of a pathway map in AD which we call “AlzPathway”, that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built the AD pathway map. AlzPathway is currently composed of thousands of molecules and reactions in neurons, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells, with their cellular localizations. AlzPathway provides a systems-biology platform of comprehensive AD signaling and related pathways which is expected to contribute to clarification of AD pathogenesis and AD drug development.

Key words

Alzheimer’s disease Systems biology Signaling pathway Pathway map Manual curation AlzPathway Drug discovery 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Soichi Ogishima
    • 1
  • Satoshi Mizuno
    • 1
  • Masataka Kikuchi
    • 2
    • 3
  • Akinori Miyashita
    • 2
  • Ryozo Kuwano
    • 2
  • Hiroshi Tanaka
    • 4
  • Jun Nakaya
    • 1
  1. 1.Department of Bioclinical Informatics, Tohoku Medical Megabank OrganizationTohoku UniversityMiyagiJapan
  2. 2.Department of Molecular Genetics, Center for Bioresources, Brain Research InstituteNiigata UniversityNiigataJapan
  3. 3.Research Association for BiotechnologyTokyoJapan
  4. 4.Department of Bioinformatics, Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan

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