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Coronaviruses: An Overview of Their Replication and Pathogenesis

  • Anthony R. Fehr
  • Stanley PerlmanEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1282)

Abstract

Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).

Key words

Nidovirales Coronavirus Positive-sense RNA viruses SARS-CoV MERS-CoV 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity of Iowa Carver College of MedicineIowa CityUSA

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