Protein-Protein Interaction Databases

Part of the Methods in Molecular Biology book series (MIMB, volume 1278)

Abstract

Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.

Key words

Protein-protein interactions Functional associations Protein-protein interaction databases Pathways Protein-protein interaction prediction Biochemical pathways Selection bias 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Faculty of Health Sciences, Novo Nordisk Foundation Centre for Protein ResearchUniversity of CopenhagenKøbenhavn NDenmark

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