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Exploring Mesenchymal Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

  • Stefania Bruno
  • Giovanni Camussi
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1213)

Abstract

Several experimental animal models have been set up to study the characteristics of acute kidney injury (AKI) and to develop possible new treatments for clinical applications. Herein, we review the experimental procedures used to induce AKI to test the therapeutic potential of extracellular vesicles (EV) produced by stem cells. In particular, we focused on AKI models induced by rhabdomyolysis, by cisplatin treatment, and by renal ischemia–reperfusion injury.

Key words

Glycerol Cisplatin Ischemia–reperfusion injury Mouse model Kidney injury Renal regeneration 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Molecular Biotechnology and Healthy Science, Molecular Biotechnology CenterUniversity of TorinoTorinoItaly
  2. 2.Department of Medical Sciences; Department of Molecular Biotechnology and Healthy ScienceUniversity of TorinoTorinoItaly

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