Host-Bacteria Interactions

Volume 1197 of the series Methods in Molecular Biology pp 287-308


Comparative Genomic Analysis at the PATRIC, A Bioinformatic Resource Center

  • Alice R. WattamAffiliated withVirginia Bioinformatics Institute, Virginia Tech Email author 
  • , Joseph L. GabbardAffiliated withVirginia Bioinformatics Institute, Virginia Tech
  • , Maulik ShuklaAffiliated withVirginia Bioinformatics Institute, Virginia Tech
  • , Bruno W. SobralAffiliated withVirginia Bioinformatics Institute, Virginia Tech

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The Pathosystems Resource Integration Center (PATRIC) is a genomics-centric relational database and bioinformatics resource designed to assist scientists in infectious-disease research. This method paper provides detailed instructions on using this resource to finding data specific to genomes, saving it in a personalized workspace and using a variety of interactive tools to analyze that data. While PATRIC contains many diverse tools and functionalities to explore both genome-scale and gene expression data, the main focus of this chapter is on comparative analysis of bacterial genomes.

Key words

Comparative genomics Metabolomics Metadata Phylogeny Genome analysis tools