Treatment of Male Infertility

  • Gianpiero D. Palermo
  • Justin Kocent
  • Devin Monahan
  • Queenie V. Neri
  • Zev Rosenwaks
Part of the Methods in Molecular Biology book series (MIMB, volume 1154)


Major difficulties exist in the accurate and meaningful diagnosis of male reproductive dysfunction, and our understanding of the epidemiology and etiology of male infertility has proven quite complex.

The numerous spermatozoa produced in mammals and other species provides some degree of protection against adverse environmental conditions represented by physical and chemical factors that can reduce reproductive function and increase gonadal damage even resulting in testicular cancer or congenital malformations. The wide fluctuations of sperm production in men, both geographical and temporal, may reflect disparate environmental exposures, occurring on differing genetic backgrounds, in varying psychosocial conditions, and leading to the diversified observed outcomes.

Sperm analysis is still the cornerstone in diagnosis of male factor infertility, indeed, individually compromised semen paramaters while adequately address therapeutic practices is progressively flanked by additional tests. Administration of drugs, IUI, correction of varicocele, and, to a certain extent, IVF although they may not be capable of restoring fertility itself often result in childbearing.

Key words

ICSI IVF Assisted fertilization Spermatogenesis Andrology Male infertility Surgically retrieved spermatozoa 



We are very appreciative to all clinicians and scientists at the The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine and the Urology Department. We are thankful to Dr. J. Michael Bedford for his critical review and for Dr. Alessia Uccelli for listing the references.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Gianpiero D. Palermo
    • 1
  • Justin Kocent
    • 1
  • Devin Monahan
    • 1
  • Queenie V. Neri
    • 1
  • Zev Rosenwaks
    • 1
  1. 1.The Ronald O. Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell Medical CollegeNew YorkUSA

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