Plant Isoprenoids: A General Overview

  • Manuel Rodríguez-Concepción
Part of the Methods in Molecular Biology book series (MIMB, volume 1153)


Borderline personality disorder (BPD) was first described 75 years ago (Stern, 1938), but only became accepted in the classification of mental disorders decades later (American Psychiatric Association, 1980); but it was at that point that research on the disorder took off. Formal investigation of BPD also led to a reformulation of its nature, moving from a condition lying on a “border” between neurosis and psychosis to a personality disorder rooted in underlying traits but associated with prominent symptoms. Thus BPD emerges from complex and interactive biological and psychosocial risk factors (Crowell, Beauchaine, & Linehan, 2009; Paris, 2007). There is no single explanation for its cause, and risks are not the same in all patients. The pathways to BPD demonstrate equifinality, with different pathways capable of leading to the same outcome (Cicchetti & Rogosch, 2002).


Borderline Personality Disorder Borderline Personality Disorder Farnesyl Diphosphate Isoprenoid Biosynthesis Isoprene Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Work in my group is supported by grants from Catalan (AGAUR 2009SGR-26), Spanish (DGI BIO2011-23680 and PIM2010IPO-00660), European (FP7 TiMet), and Ibero-American (CYTED 112RT0445-IBERCAROT) agencies.


  1. 1.
    Croteau R, Kutchan T, Lewis N (2000) Natural products (secondary metabolites). In: Buchanan B, Gruissem W, Jones R (eds) Biochemistry and molecular biology of plants. American Society of Plant Biologists, Rockville, MD, pp 1250–1268Google Scholar
  2. 2.
    Bouvier F, Rahier A, Camara B (2005) Biogenesis, molecular regulation and function of plant isoprenoids. Prog Lipid Res 44:357–429PubMedCrossRefGoogle Scholar
  3. 3.
    Tholl D, Lee S (2011) Terpene specialized metabolism in Arabidopsis thaliana. Arabidopsis Book 9:e0143PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Hemmerlin A, Harwood JL, Bach TJ (2012) A raison d'etre for two distinct pathways in the early steps of plant isoprenoid biosynthesis? Prog Lipid Res 51:95–148PubMedCrossRefGoogle Scholar
  5. 5.
    Vranova E, Coman D, Gruissem W (2013) Network analysis of the MVA and MEP pathways for isoprenoid synthesis. Annu Rev Plant Biol 64:665–700PubMedCrossRefGoogle Scholar
  6. 6.
    Pulido P, Perello C, Rodriguez-Concepcion M (2012) New insights into plant isoprenoid metabolism. Mol Plant 5:964–967PubMedCrossRefGoogle Scholar
  7. 7.
    Chappell J (1995) Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants. Annu Rev Plant Physiol Plant Mol Biol 46:521–547CrossRefGoogle Scholar
  8. 8.
    Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425–430PubMedCrossRefGoogle Scholar
  9. 9.
    Lichtenthaler HK (1999) The 1-deoxy-d-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annu Rev Plant Physiol Plant Mol Biol 50:47–65PubMedCrossRefGoogle Scholar
  10. 10.
    Rohmer M (1999) The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat Prod Rep 16:565–574PubMedCrossRefGoogle Scholar
  11. 11.
    Phillips MA, Leon P, Boronat A, Rodriguez-Concepcion M (2008) The plastidial MEP pathway: unified nomenclature and resources. Trends Plant Sci 13:619–623PubMedCrossRefGoogle Scholar
  12. 12.
    Rodríguez-Concepción M, Boronat A (2002) Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol 130:1079–1089PubMedCrossRefGoogle Scholar
  13. 13.
    Lange BM, Ghassemian M (2003) Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. Plant Mol Biol 51:925–948PubMedCrossRefGoogle Scholar
  14. 14.
    Beck G, Coman D, Herren E, Ruiz-Sola MA, Rodriguez-Concepcion M, Gruissem W, Vranova E (2013) Characterization of the GGPP synthase gene family in Arabidopsis thaliana. Plant Mol Biol 82:393–416PubMedCrossRefGoogle Scholar
  15. 15.
    Kasahara H, Hanada A, Kuzuyama T, Takagi M, Kamiya Y, Yamaguchi S (2002) Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. J Biol Chem 277:45188–45194PubMedCrossRefGoogle Scholar
  16. 16.
    Flores-Perez U, Perez-Gil J, Closa M, Wright LP, Botella-Pavia P, Phillips MA, Ferrer A, Gershenzon J, Rodriguez-Concepcion M (2010) PLEIOTROPIC REGULATORY LOCUS 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis. Mol Plant 3:101–112PubMedCrossRefGoogle Scholar
  17. 17.
    Rodríguez-Concepción M, Campos N, Ferrer A, Boronat A (2013) Biosynthesis of isoprenoid precursors in Arabidopsis. In: Bach TJ, Rohmer M (eds) Isoprenoid synthesis in plants and microorganisms: new concepts and experimental approaches. Springer, New York, pp 436–456Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Centre for Research in Agricultural Genomics (CRAG)CSIC-IRTA-UAB-UBBarcelonaSpain

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