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Introduction: Esophageal Squamous Cell Carcinoma—Current Status and Future Advances

  • Alfred K. LamEmail author
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Part of the Methods in Molecular Biology book series (MIMB, volume 2129)

Abstract

Esophageal squamous cell carcinoma is the most common histological subtype of esophageal cancer. The carcinoma is more common in high-incidence areas such as in Central and Southeast Asia, Eastern and Southern Africa, South America, etc. Common risk factors associated with the cancer are tobacco smoking and excessive alcohol consumption. Dietary factors, genetic factors, microorganisms, and some other environmental factors may contribute to the etiopathogenesis of the disease. Despite the global incidence of esophageal squamous cell carcinoma decreases slightly in the recent years, esophageal squamous cell carcinoma is still a major cause of cancer-related morbidity and mortality worldwide. Further improvement of the outcomes of the patients with the disease could be achieved by early diagnosis, collaborative efforts of multidisciplinary clinical and research teams, use of standardized protocol for pathological reporting and staging of the disease, proper use of cancer tissue, as well as improvement in clinical, pathological, therapeutic, and research approaches to the cancer.

Key words

Esophageal Squamous cell carcinoma Epidemiology Incidence Metastases ICCR 

References

  1. 1.
    Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M et al (2015) The global burden of cancer 2013. JAMA Oncol 1:505–527CrossRefGoogle Scholar
  2. 2.
    Malhotra GK, Yanala U, Ravipati A, Follet M, Vijayakumar M, Are C (2017) Global trends in esophageal cancer. J Surg Oncol 115:564–579CrossRefGoogle Scholar
  3. 3.
    Wang SM, Abnet CC, Qiao YL (2019) What have we learned from Linxian esophageal cancer etiological studies? Thorac Cancer 10:1036–1042CrossRefGoogle Scholar
  4. 4.
    Shin A, Won YJ, Jung HK, Kong HJ, Jung KW, Oh CM, Choe S, Lee J (2018) Trends in incidence and survival of esophageal cancer in Korea: analysis of the Korea Central Cancer Registry Database. J Gastroenterol Hepatol 33:1961–1968CrossRefGoogle Scholar
  5. 5.
    Wang QL, Xie SH, Wahlin K, Lagergren J (2018) Global time trends in the incidence of esophageal squamous cell carcinoma. Clin Epidemiol 10:717–728CrossRefGoogle Scholar
  6. 6.
    Lam AK (2018) Introduction: esophageal adenocarcinoma: updates of current status. Methods Mol Biol 1756:1–6CrossRefGoogle Scholar
  7. 7.
    Xie SH, Lagergren J (2018) Risk factors for oesophageal cancer. Best Pract Res Clin Gastroenterol 36-37:3–8CrossRefGoogle Scholar
  8. 8.
    Abnet CC, Arnold M, Wei WQ (2018) Epidemiology of esophageal squamous cell carcinoma. Gastroenterology 154:360–373CrossRefGoogle Scholar
  9. 9.
    Sheikh M, Poustchi H, Pourshams A, Etemadi A, Islami F, Khoshnia M, Gharavi A, Hashemian M, Roshandel G, Khademi H, Zahedi M, Abedi-Ardekani B, Boffetta P, Kamangar F, Dawsey SM, Pharaoh PD, Abnet CC, Day NE, Brennan P, Malekzadeh R (2019) Individual and combined effects of environmental risk factors for esophageal cancer based on results from the Golestan cohort study. Gastroenterology 156:1416–1427CrossRefGoogle Scholar
  10. 10.
    Castro C, Peleteiro B, Lunet N (2018) Modifiable factors and esophageal cancer: a systematic review of published meta-analyses. J Gastroenterol 53:37–51CrossRefGoogle Scholar
  11. 11.
    Akhtar S (2013) Areca nut chewing and esophageal squamous-cell carcinoma risk in Asians: a meta-analysis of case-control studies. Cancer Causes Control 24:257–265CrossRefGoogle Scholar
  12. 12.
    Mwachiro MM, Parker RK, Pritchett NR, Lando JO, Ranketi S, Murphy G, Chepkwony R, Burgert SL, Abnet CC, Topazian MD, Dawsey SM, White RE (2019) Investigating tea temperature and content as risk factors for esophageal cancer in an endemic region of Western Kenya: Validation of a questionnaire and analysis of polycyclic aromatic hydrocarbon content. Cancer Epidemiol 60:60–66CrossRefGoogle Scholar
  13. 13.
    Hošnjak L, Poljak M (2018) A systematic literature review of studies reporting human papillomavirus (HPV) prevalence in esophageal carcinoma over 36 years (1982-2017). Acta Dermatovenerol Alp Pannonica Adriat 27:127–136PubMedGoogle Scholar
  14. 14.
    He D, Zhang DK, Lam KY, Ma L, Ngan HY, Liu SS, Tsao SW (1997) Prevalence of HPV infection in esophageal squamous cell carcinoma in Chinese patients and its relationship to the p53 gene mutation. Int J Cancer 72:959–964CrossRefGoogle Scholar
  15. 15.
    Lam KY, He D, Ma L, Zhang D, Ngan HY, Wan TS, Tsao SW (1997) Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutation. Hum Pathol 28:657–663CrossRefGoogle Scholar
  16. 16.
    Lam AK (2000) Molecular biology of esophageal squamous cell carcinoma. Crit Rev Oncol Hematol 33:71–90CrossRefGoogle Scholar
  17. 17.
    Talagala IA, Nawarathne M, Arambepola C (2018) Novel risk factors for primary prevention of oesophageal carcinoma: a case-control study from Sri Lanka. BMC Cancer 18:1135CrossRefGoogle Scholar
  18. 18.
    Ellis A, Risk JM, Maruthappu T, Kelsell DP (2015) Tylosis with oesophageal cancer: diagnosis, management and molecular mechanisms. Orphanet J Rare Dis 10:126CrossRefGoogle Scholar
  19. 19.
    Itskoviz D, Tamary H, Krasnov T, Yacobovich J, Sahar N, Zevit N, Shamir R, Ben-Bassat O, Leibovici Wiseman Y, Dickman R, Ringel Y, Dotan I, Goldberg Y, Morgenstern S, Levi Z (2019) Endoscopic findings and esophageal cancer incidence among Fanconi Anemia patients participating in an endoscopic surveillance program. Dig Liver Dis 51:242–246CrossRefGoogle Scholar
  20. 20.
    Donner I, Katainen R, Tanskanen T, Kaasinen E, Aavikko M, Ovaska K, Artama M, Pukkala E, Aaltonen LA (2017) Candidate susceptibility variants for esophageal squamous cell carcinoma. Genes Chromosomes Cancer 56:453–459CrossRefGoogle Scholar
  21. 21.
    Ponds FA, Moonen A, Smout AJPM, Rohof WOA, Tack J, van Gool S, Bisschops R, Bredenoord AJ, Boeckxstaens GE (2018) Screening for dysplasia with Lugol chromoendoscopy in longstanding idiopathic achalasia. Am J Gastroenteol 113:855–862CrossRefGoogle Scholar
  22. 22.
    Nasa M, Patil G, Sharma Z, Puri R (2017) Plummer-Vinson syndrome with simultaneous mid-esophageal growth. J Assoc Physicians India 65:96–97PubMedGoogle Scholar
  23. 23.
    Priante AV, Castilho EC, Kowalski LP (2011) Second primary tumors in patients with head and neck cancer. Curr Oncol 13:132–137CrossRefGoogle Scholar
  24. 24.
    Dawsey SM, Lewin KJ, Wang GQ, Liu FS, Nieberg RK, Yu Y, Li JY, Blot WJ, Li B, Taylor PR (1994) Squamous esophageal histology and subsequent risk of squamous cell carcinoma of the esophagus. A prospective follow-up study from Linxian, China. Cancer 74:1686–1692CrossRefGoogle Scholar
  25. 25.
    Wang GQ, Abnet CC, Shen Q, Lewin KJ, Sun XD, Roth MJ, Qiao YL, Mark SD, Dong ZW, Taylor PR, Dawsey SM (2005) Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut 54:187–192CrossRefGoogle Scholar
  26. 26.
    Lam KY, Law S, Tin L, Tung PH, Wong J (1999) The clinicopathological significance of p21 and p53 expression in esophageal squamous cell carcinoma: an analysis of 153 patients. Am J Gastroenterol 94:2060–2068CrossRefGoogle Scholar
  27. 27.
    Lam KY, Ma L (1997) Pathology of esophageal cancers: local experience and current insights. Chin Med J 110:459–464PubMedGoogle Scholar
  28. 28.
    Lagergren J, Smyth E, Cunningham D, Lagergren P (2017) Oesophageal cancer. Lancet 390:2383–2396CrossRefGoogle Scholar
  29. 29.
    Lam KY, Law S, Wong J (2003) Low prevalence of incidentally discovered and early stage esophageal cancers in a 30-year autopsy study. Dis Esophagus 16:1–3CrossRefGoogle Scholar
  30. 30.
    Wu SG, Zhang WW, Sun JY, Li FY, Lin Q, He ZY (2018) Patterns of distant metastasis between histological types in esophageal cancer. Front Oncol 8:302CrossRefGoogle Scholar
  31. 31.
    Lam KY, Lo CY (2002) Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital. Clin Endocrinol 56:95–101CrossRefGoogle Scholar
  32. 32.
    Lam KY, Dickens P, Chan AC, Tumors of the heart (1993) A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 117:1027–1031PubMedGoogle Scholar
  33. 33.
    Lam KY, Tang V (2000) Metastatic tumors to the spleen: a 25-year clinicopathologic study. Arch Pathol Lab Med 124:526–530PubMedGoogle Scholar
  34. 34.
    Codipilly DC, Qin Y, Dawsey SM, Kisiel J, Topazian M, Ahlquist D, Iyer PG (2018) Screening for esophageal squamous cell carcinoma: recent advances. Gastrointest Endosc 88:413–426CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Cancer Molecular Pathology, School of MedicineGriffith UniversityGold CoastAustralia

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