Nanoparticles for Immune Cell Reprogramming and Reengineering of Tumor Microenvironment

  • Ketki Bhise
  • Samaresh Sau
  • Rami Alzhrani
  • Arun K. IyerEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 2097)


Nanoparticles in cancer therapy have garnered significant attention in the past few decades. Cancer immunotherapy, which is aptly called “the new-generation cancer therapy,” is slowly making remarkable strides in the improvement of patient outcome and longevity. Taken together, nanoparticles in immune therapy have the potential to offer advantages of both nanoparticles and immune therapy on a single platform.


Cancer Macrophage polarization Immune therapy Immune cell reprogramming Nanoparticles 



The authors acknowledge partial support for this work by Wayne State University startup funding. A.K.I. acknowledges a grant from the Department of Defense (DoD) CDMRP KCRP Idea Development Award (#W81XWH-18-1-0471) as an Early Career Investigator. S.S. and A.K.I. acknowledge a grant support from the Burroughs Wellcome Trust. K.B. acknowledges Thomas C. Rumble University Graduate Fellowship and Graduate Research Fellowship from the Wayne State University. R.A. acknowledges the scholarship support from College of Pharmacy at Taif University and Saudi Arabian Cultural Mission (SACM).


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Ketki Bhise
    • 1
  • Samaresh Sau
    • 1
  • Rami Alzhrani
    • 1
  • Arun K. Iyer
    • 1
    • 2
    Email author
  1. 1.Use-Inspired Biomaterials and Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical SciencesWayne State UniversityDetroitUSA
  2. 2.Molecular Imaging ProgramKarmanos Cancer InstituteDetroitUSA

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