QSAR Approaches and Ecotoxicological Risk Assessment

  • Mabrouk Hamadache
  • Othmane Benkortbi
  • Abdeltif AmraneEmail author
  • Salah Hanini
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


Hundreds of thousands of chemicals that can affect human health or the quality of aquatic and terrestrial ecosystems are introduced directly or indirectly into the air, water, or soil. Therefore, the awareness of the serious and harmful effects caused by these chemical compounds has revealed the absolute and compelling need to resort to the evaluation of potential risks incurred as a result of exposure to these compounds. In the aim to provide a high level of protection for human, animal, and environmental health, many regulatory agencies have established strict legislation for both toxicological and ecotoxicological risk assessments of existing and new chemical compounds. To limit the in vivo experiments which are a tedious and costly practice and generate a large sacrifice of animals, the REACH regulation recommends the use of in silico methods, such as quantitative structure–activity relationship (QSAR) models.

Key words

Ecosystems Pollutants Ecotoxicity QSAR models Adverse effects 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Mabrouk Hamadache
    • 1
  • Othmane Benkortbi
    • 1
  • Abdeltif Amrane
    • 2
    Email author
  • Salah Hanini
    • 1
  1. 1.Laboratoire des Biomatériaux et Phénomènes de Transport (LBMPT)Université Yahia Fares de MédéaMedeaAlgeria
  2. 2.Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR - UMR 6226, F-35000RennesFrance

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