pp 1-30 | Cite as

Lesion-Behavior Mapping in Cognitive Neuroscience: A Practical Guide to Univariate and Multivariate Approaches

  • Hans-Otto KarnathEmail author
  • Christoph Sperber
  • Daniel Wiesen
  • Bianca de Haan
Part of the Neuromethods book series


Lesion-behavior mapping is an influential and popular approach to anatomically localize cognitive brain functions in the human brain. The present chapter provides a practical guideline for each step of the typical lesion-behavior mapping study pipeline, ranging from patient and imaging data, lesion delineation, spatial normalization, and statistical testing to the anatomical interpretation of results. An important aspect of this guideline at the statistical level will be to address the procedures related to univariate as well as multivariate voxelwise lesion analysis approaches.


Lesion analysis Univariate voxel-based lesion-symptom mapping Multivariate voxel-based lesion-symptom mapping Multivariate pattern analysis VLSM VLBM MLBM MVPA Brain behavior inference Stroke Human 



This work was supported by the Deutsche Forschungsgemeinschaft (KA 1258/23-1). Daniel Wiesen was supported by the Luxembourg National Research Fund (FNR/11601161).


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Copyright information

© Springer Science+Business Media, LLC 2019

Authors and Affiliations

  • Hans-Otto Karnath
    • 1
    Email author
  • Christoph Sperber
    • 1
  • Daniel Wiesen
    • 1
  • Bianca de Haan
    • 2
  1. 1.Division of Neuropsychology, Center of Neurology, Hertie-Institute for Clinical Brain ResearchUniversity of TübingenTübingenGermany
  2. 2.Division of Psychology, Department of Life Sciences, College of Health and Life SciencesBrunel University LondonUxbridgeUK

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