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Detection of Autoantibodies Against Myelin Oligodendrocyte Glycoprotein in Multiple Sclerosis and Related Diseases

  • Melania Spadaro
  • Edgar Meinl
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1304)

Abstract

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with different inflammatory demyelinating diseases of the central nervous system, such as childhood multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica spectrum disorders (NMOSD). We describe here in detail a sensitive cell-based assay that allows the identification of autoantibodies against MOG in serum.

Keywords

MOG NMOSD MS Demyelination Autoantibody 

Notes

Acknowledgement

This work was supported by the Deutsche Forschungsgemeinschaft (SFB-TR 128; SyNergy), the Klinische Kompetenznetz Multiple Sklerose, Verein zur Therapieforschung für MS Kranke, Werner Reichenberger Stiftung, and Gemeinnützige Hertie Stiftung.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Institute of Clinical Neuroimmunology, Medical Campus GrosshadernLudwig Maximilian UniversityMunichGermany

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