Biomimetic Strategies Incorporating Enzymes into CaP Coatings Mimicking the In Vivo Environment
Biomimetic calcium phosphate coating (CaP) methodology mimics the natural biomineralization process of bone, which involves two phases: nucleation and growth. In this chapter we present a successful method to coating biodegradable natural-origin materials with biomimetic CaP layer as a strategy to incorporate enzymes with the main aim of controlling and tailoring their degradation over time. This strategy seems to enhance the bone-bonding, osteoconductive, and osteoinductive properties of natural-origin biomaterials that per se do not present these characteristics.
KeywordsNatural-origin biomaterials Biomimetics CaP coatings Enzymes
A.M.M. acknowledges “Fundação para a Ciência e Tecnologia” (FCT) for the Postdoctoral grant (SFRH/BPD/66897/2009) financed by POPH-QREN-Advanced Formation, and co-financed by Social European Fund and National Fund from MCTES.
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