Magnetic Resonance Imaging and Tracking of Stem Cells

  • Hossein Nejadnik
  • Rostislav Castillo
  • Heike E. Daldrup-Link
Part of the Methods in Molecular Biology book series (MIMB, volume 1052)


To date, several stem cell labeling protocols have been developed, contributing to a fast growing and promising field of stem cell imaging by MRI (magnetic resonance imaging). Most of these methods utilize iron oxide nanoparticles (MION, SPIO, USPIO, VSIOP) for cell labeling, which provide negative (dark) signal effects on T2-weighted MR images. The following protocol describes stem cell labeling techniques with commercially available gadolinium chelates, which provide positive contrast on T1-weighted MR images, which can be advantageous for specific applications.


Magnetic resonance imaging (MRI) Stem cells Cell labeling Cell tracking Cellular imaging ProHance® Gadoteridol Gadolinium chelate 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hossein Nejadnik
    • 1
  • Rostislav Castillo
    • 1
  • Heike E. Daldrup-Link
    • 1
  1. 1.Department of Radiology, Molecular Imaging Program at StanfordStanford UniversityStanfordUSA

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