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Conducting Molecular Biomarker Discovery Studies in Plants

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High-Throughput Phenotyping in Plants

Part of the book series: Methods in Molecular Biology ((MIMB,volume 918))

Abstract

Molecular biomarkers are molecules whose concentrations in a biological system inform about the current phenotypical state and, more importantly, may also be predictive of future phenotypic trait endpoints. The identification of biomarkers has gained much attention in targeted plant breeding since technologies have become available that measure many molecules across different levels of molecular organization and at decreasing costs. In this chapter, we outline the general strategy and workflow of conducting biomarker discovery studies. Critical aspects of study design as well as the statistical data analysis and model building will be highlighted.

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Acknowledgments

Support for this work was provided by the BMELV-funded TROST and the BMBF-funded SEPSAPE projects.

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Authors and Affiliations

  1. Max Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany

    Christian Schudoma, Matthias Steinfath, Heike Sprenger, Joost T. van Dongen, Dirk Hincha, Ellen Zuther, Joachim Kopka, Karin Köhl & Dirk Walther

  2. Department Biologie I, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany

    Peter Geigenberger

Authors
  1. Christian Schudoma
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  2. Matthias Steinfath
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  3. Heike Sprenger
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  4. Joost T. van Dongen
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  5. Dirk Hincha
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  6. Ellen Zuther
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  7. Peter Geigenberger
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  8. Joachim Kopka
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  9. Karin Köhl
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  10. Dirk Walther
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Corresponding author

Correspondence to Dirk Walther .

Editor information

Editors and Affiliations

  1. , Dept. of Biochemistry & Molecular Biolog, University of Massachusetts, N. Pleasant Street 710, Amherst, 01003, USA

    Jennifer Normanly

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Schudoma, C. et al. (2012). Conducting Molecular Biomarker Discovery Studies in Plants. In: Normanly, J. (eds) High-Throughput Phenotyping in Plants. Methods in Molecular Biology, vol 918. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-995-2_10

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  • DOI: https://doi.org/10.1007/978-1-61779-995-2_10

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-994-5

  • Online ISBN: 978-1-61779-995-2

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