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Autophagy in Disease

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Protein Misfolding and Cellular Stress in Disease and Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 648))

Abstract

Autophagy is a cellular quality control process by which cytoplasmic constituents including proteins, protein aggregates, organelles, and invading pathogens can be delivered to lysosomes for degradation. Autophagy is activated in response to changes in the internal status of the cell and/or changes in the extracellular environment. It is therefore essential for the maintenance of cellular homeostasis and for an efficient response to cellular stresses. As such autophagy has been implicated either in the pathogenesis, or response to a wide variety of diseases, bacterial, and viral infections, and ageing.

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Acknowledgments

We apologise to investigators whose important original contributions have not been cited; where possible we have chosen to cite recent reviews in which details of such contributions can be found.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia

    Dalibor Mijaljica & Mark Prescott

  2. Department of Biochemistry and Molecular Biology and the ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC, Australia

    Rodney J. Devenish

Authors
  1. Dalibor Mijaljica
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  2. Mark Prescott
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  3. Rodney J. Devenish
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Corresponding author

Correspondence to Rodney J. Devenish .

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Editors and Affiliations

  1. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Peter Bross

  2. Aarhus University Hospital, Research Unit for Molecular Medicine, University of Aarhus, Brendstrupgaardsvej 100, Aarhus N, 8200, Denmark

    Niels Gregersen

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Mijaljica, D., Prescott, M., Devenish, R.J. (2010). Autophagy in Disease. In: Bross, P., Gregersen, N. (eds) Protein Misfolding and Cellular Stress in Disease and Aging. Methods in Molecular Biology, vol 648. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-756-3_5

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  • DOI: https://doi.org/10.1007/978-1-60761-756-3_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-755-6

  • Online ISBN: 978-1-60761-756-3

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