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Cell Fusion pp 3–20Cite as

Yeast Mating

A Model System for Studying Cell and Nuclear Fusion

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 475))

Summary

Haploid yeast cells mate to form a zygote, whose progeny are diploid cells. A fundamentally sexual event, related to fertilization, yeast mating nevertheless exhibits cytological properties that appear similar to somatic cell fusion. A large collection of mutations that lead to defects in various stages of mating, including cell fusion, has allowed a detailed dissection of the overall pathway. Recent advances in imaging methods, together with powerful methods of genetic analysis, make yeast mating a superb platform for investigation of cell fusion. An understanding of yeast cell fusion will provide insight into fundamental mechanisms of cell signaling, cell polarization, and membrane fusion.

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  1. Department of Molecular Biology, Princeton University, Princeton, NJ

    Casey A. Ydenberg & Mark D. Rose

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  1. Casey A. Ydenberg
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  2. Mark D. Rose
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  1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD

    Elizabeth H. Chen

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Ydenberg, C.A., Rose, M.D. (2008). Yeast Mating. In: Chen, E.H. (eds) Cell Fusion. Methods in Molecular Biology™, vol 475. Humana Press. https://doi.org/10.1007/978-1-59745-250-2_1

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  • DOI: https://doi.org/10.1007/978-1-59745-250-2_1

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