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The Canonical Wnt/β-Catenin Signalling Pathway

  • Protocol
Wnt Signaling

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 468))

Abstract

Embryonic development of multicellular organisms is an incredibly complex process that relies heavily on evolutionarily conserved signalling pathways to provide crucial cell cell communication. Typically, secreted signalling proteins such as Wnts, BMPs, and Hedgehogs released by one cell population will trigger concentration-dependent responses in other cells located some distance away. In adults, the same signalling pathways orchestrate tissue renewal in organs such as the intestine and skin, and direct tissue regeneration in many organs following injury. Strict regulation of these signalling pathways is critical, with insufficient or excess activity having catastrophic consequences including severe developmental defects or, later in life, cancer. This chapter deals with the β-catenin-dependent branch of Wnt signalling (also referred to the canonical pathway).

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Author information

Authors and Affiliations

  1. Hubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands

    Nick Barker

Authors
  1. Nick Barker
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Editor information

Editors and Affiliations

  1. University of Melbourne, Parkville, Victoria, VIC 3010, Australia

    Elizabeth Vincan PhD

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Barker, N. (2008). The Canonical Wnt/β-Catenin Signalling Pathway. In: Vincan, E. (eds) Wnt Signaling. Methods in Molecular Biology™, vol 468. Humana Press. https://doi.org/10.1007/978-1-59745-249-6_1

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  • DOI: https://doi.org/10.1007/978-1-59745-249-6_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-912-3

  • Online ISBN: 978-1-59745-249-6

  • eBook Packages: Springer Protocols

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