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Cardiac Gene Expression pp 229–251Cite as

Comparative Genomics

A Tool to Functionally Annotate Human DNA

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 366))

Abstract

The availability of an increasing number of vertebrate genomes has enabled comparative methods to infer functional sequences based on evolutionary constraint. Although this has proved powerful for gene identification, significant progress has also been made in uncovering gene regulatory sequences such as distant acting transcriptional enhancers. These pursuits have led to the development of a variety of valuable databases and resources that should serve as a routine toolbox for biological discovery.

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Author information

Authors and Affiliations

  1. Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Jan-Fang Cheng, James R. Priest & Len A. Pennacchio

  2. Joint Genome Institute, U.S. Department of Energy, Walnut Creek, CA, USA

    Jan-Fang Cheng, James R. Priest & Len A. Pennacchio

Authors
  1. Jan-Fang Cheng
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  2. James R. Priest
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  3. Len A. Pennacchio
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Editor information

Editors and Affiliations

  1. Division of Cardiology, CVRL/Geffen School of Medicine at UCLA, Los Angeles, CA

    Jun Zhang

  2. Division of Cardiology, University of Louisville, Louisville, KY

    Gregg Rokosh

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© 2007 Humana Press Inc.

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Cheng, JF., Priest, J.R., Pennacchio, L.A. (2007). Comparative Genomics. In: Zhang, J., Rokosh, G. (eds) Cardiac Gene Expression. Methods in Molecular Biology, vol 366. Humana Press. https://doi.org/10.1007/978-1-59745-030-0_13

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  • DOI: https://doi.org/10.1007/978-1-59745-030-0_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-352-7

  • Online ISBN: 978-1-59745-030-0

  • eBook Packages: Springer Protocols

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