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Biobanking pp 77–87Cite as

Autopsy Biobanking: Biospecimen Procurement, Integrity, Storage, and Utilization

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1897))

Abstract

An autopsy is a specialized surgical procedure consisting of external and internal examination of a deceased individual for the purposes of documenting abnormalities and determining or confirming medical diagnoses that may have contributed to their death. One of the benefits of an autopsy is the opportunity to collect and store biospecimens for the purposes of biobanking. This chapter outlines the procedures necessary to procure, store, and utilize biospecimens obtained during an autopsy. With the emergence of molecular diagnostics, this chapter also discusses factors that influence the integrity of autopsy biospecimens prior to procurement. These include the postmortem interval, as well as premortem factors such as the patient’s agonal state, biospecimen temperature, and pH.

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Acknowledgments

This work was supported in part by NIH:NCI P50-CA211015, NIH:NIMH U24 MH100929, the Art of the Brain Foundation, and the Henry E. Singleton Brain Cancer Research Program.

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Randy S. Tashjian, Ryan R. Williams, Harry V. Vinters & William H. Yong

  2. Brain Tumor Translational Resource, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Harry V. Vinters & William H. Yong

  3. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Harry V. Vinters & William H. Yong

Authors
  1. Randy S. Tashjian
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  2. Ryan R. Williams
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  3. Harry V. Vinters
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  4. William H. Yong
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Corresponding author

Correspondence to William H. Yong .

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Editors and Affiliations

  1. Division of Neuropathology, Department of Pathology and Laboratory Medicine, Brain Tumor Translational Resource, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    William H. Yong

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Tashjian, R.S., Williams, R.R., Vinters, H.V., Yong, W.H. (2019). Autopsy Biobanking: Biospecimen Procurement, Integrity, Storage, and Utilization. In: Yong, W. (eds) Biobanking. Methods in Molecular Biology, vol 1897. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8935-5_8

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  • DOI: https://doi.org/10.1007/978-1-4939-8935-5_8

  • Published:

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8933-1

  • Online ISBN: 978-1-4939-8935-5

  • eBook Packages: Springer Protocols

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