Abstract
Many tests are available for the assessment of cognitive function. This chapter describes the common features and practical requirements of test administration, key considerations in the selection and interpretation of tests, and their application in Alzheimer’s disease drug development.
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References
Kipps CM, Hodges JR (2005) Cognitive assessment for clinicians. J Neurol Neurosurg Psychiatry 76(Suppl I):i22–i30
Randolph C (1998) Repeatable battery for the assessment of neuropsychological status: manual. Pearson, Bloomington
Stern RA, White T (2003) Neuropsychological assessment battery: administration, scoring, and interpretation manual. PAR, Inc., Lutz, FL
Benedict R, Brandt J (1997) Brief visuospatial memory test—revised (BVMT-R). PAR, Inc., Lutz, FL
Wechsler D (1997) Wechsler memory scale—third edition (WMS–III) administration and scoring manual. The Psychological Corporation, San Antonio, TX
Knight C, Alderman N, Burgess PW (2002) Development of a simplified version of the multiple errands test for use in hospital settings. Neuropsychol Rehabil 12(3):231–255
Reitan RM, Wolfson D (1985) The Halstead–Reitan neuropsychological test battery: theory and clinical interpretation. Neuropsychological Press, Tucson, AZ
Wechsler D (2008) Wechsler adult intelligence scale—fourth edition (WAIS-IV) administration and scoring manual. The Psychological Corporation, San Antonio, TX
Folstein M, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198
Bartels C, Wegrzyn M, Wiedl A, Ackermann V, Ehrenreich H (2010) Practice effects in healthy adults: a longitudinal study on frequent repetitive cognitive testing. BMC Neurosci 11:118
Beglinger LJ, Gaydos B, Tangphao-Daniels O et al (2005) Practice effects and the use of alternate forms in serial neuropsychological testing. Arch Clin Neuropsychol 20(4):517–529
McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34(7):939–944
Dubois B, Feldman HH, Jacova C et al (2007) Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6(8):734–746
Simard M (1998) The mini-mental state examination: strengths and weaknesses of a clinical instrument. Can Alzheimer Dis Rev 12:10–12
Donohue MC, Sperling RA, Salmon DP et al (2014) The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol 71(8):961–970
Fray PJ, Robbins TW, Sahakian BJ (1996) Neuropsychiatric applications of CANTAB. Int J Geriatr Psychiatry 11:329–336
Harrison J, Minassian SL, Jenkins L, Black RS, Koller M, Grundman M (2007) A neuropsychological test battery for use in Alzheimer disease clinical trials. Arch Neurol 64(9):1323–1329
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Price, G. (2018). Cognitive Assessment in Alzheimer’s Disease Clinical Trials. In: Perneczky, R. (eds) Biomarkers for Alzheimer’s Disease Drug Development. Methods in Molecular Biology, vol 1750. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7704-8_24
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DOI: https://doi.org/10.1007/978-1-4939-7704-8_24
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