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Progress and Potential of Imaging Mass Spectrometry Applied to Biomarker Discovery

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Neuroproteomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1598))

Abstract

Mapping provides a direct means to assess the impact of protein biomarkers and puts into context their relevance in the type of cancer being examined. To this end, mass spectrometry imaging (MSI) was developed to provide the needed spatial information which is missing in traditional liquid-based mass spectrometric proteomics approaches. Aptly described as a “molecular histology” technique, MSI gives an additional dimension in characterizing tumor biopsies, allowing for mapping of hundreds of molecules in a single analysis. A decade of developments focused on improving and standardizing MSI so that the technique can be translated into the clinical setting. This review describes the progress made in addressing the technological development that allows to bridge local protein detection by MSI to its identification and to illustrate its potential in studying various aspects of cancer biomarker discovery.

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Authors and Affiliations

  1. Université de Lille 1, INSERM, U1192—Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM), 59000, Lille, France

    Jusal Quanico, Julien Franck, Maxence Wisztorski, Michel Salzet & Isabelle Fournier

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  1. Jusal Quanico
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  2. Julien Franck
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  3. Maxence Wisztorski
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  4. Michel Salzet
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  5. Isabelle Fournier
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Correspondence to Isabelle Fournier .

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Editors and Affiliations

  1. Department of Psychiatry, University of Florida McKnight Brain Institute, Gainesville, Florida, USA

    Firas H. Kobeissy

  2. Department of Cell Biology, Microbiology, & Molecular Biology, University of South Florida, Tampa, Florida, USA

    Stanley M. Stevens, Jr.

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Quanico, J., Franck, J., Wisztorski, M., Salzet, M., Fournier, I. (2017). Progress and Potential of Imaging Mass Spectrometry Applied to Biomarker Discovery. In: Kobeissy, F., Stevens, Jr., S. (eds) Neuroproteomics. Methods in Molecular Biology, vol 1598. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6952-4_2

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  • DOI: https://doi.org/10.1007/978-1-4939-6952-4_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6950-0

  • Online ISBN: 978-1-4939-6952-4

  • eBook Packages: Springer Protocols

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