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The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance

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Book cover Cancer Drug Resistance

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1395))

Abstract

Recent genomic and transcriptomic analysis has revealed that the majority of the human genome is transcribed as nonprotein-coding RNA. These transcripts, known as long noncoding RNA, have structures similar to those of mRNA. Many of these transcripts are now thought to have regulatory roles in different biological pathways which provide cells with an additional layer of regulatory complexity in gene expression and proteome function in response to stimuli. A wide variety of cellular functions may thus depend on the fine-tuning of interactions between noncoding RNAs and other key molecules in cell signaling networks. Deregulation of many noncoding RNAs is thought to occur in a variety of human diseases, including neoplasia and cancer drug resistance. Here we discuss recent findings on the molecular functions of long noncoding RNAs in cellular pathways mediating resistance to anticancer drugs.

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Authors and Affiliations

  1. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand

    Marjan E. Askarian-Amiri, Euphemia Leung, Graeme Finlay & Bruce C. Baguley

  2. Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

    Marjan E. Askarian-Amiri, Euphemia Leung & Graeme Finlay

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  1. Marjan E. Askarian-Amiri
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  2. Euphemia Leung
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Correspondence to Marjan E. Askarian-Amiri .

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  1. New University of Lisbon, Lisbon, Portugal

    Jose Rueff

  2. New University of Lisbon, Lisbon, Portugal

    António Sebastião Rodrigues

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Askarian-Amiri, M.E., Leung, E., Finlay, G., Baguley, B.C. (2016). The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance. In: Rueff, J., Rodrigues, A. (eds) Cancer Drug Resistance. Methods in Molecular Biology, vol 1395. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3347-1_12

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  • DOI: https://doi.org/10.1007/978-1-4939-3347-1_12

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