Arterial Chemoreception

1. Front Matter

   Pages i-xxiv

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2. The Role of Hypoxia-Inducible Factors in Oxygen Sensing by the Carotid Body

   • Gregg L. Semenza, Nanduri R. Prabhakar

   Pages 1-5

3. Neuronal Mechanisms of Oxygen Chemoreception: An Invertebrate Perspective

   • Tara A. Janes, Naweed I. Syed

   Pages 7-17

4. Peripheral Chemoreceptors in Air- Versus Water- Breathers

   • Michael G. Jonz, Colin A. Nurse

   Pages 19-27

5. Sex-Specific Effects of Daily Gavage with a Mixed Progesterone and Glucocorticoid Receptor Antagonist on Hypoxic Ventilatory Response in Newborn Rats

   • Stéphanie Fournier, Van Diep Doan, Vincent Joseph

   Pages 29-35

6. Age-Dependent Changes in Breathing Stability in Rats

   • Lalah M. Niane, Aida Bairam

   Pages 37-41

7. Dose Dependent Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats

   • Oubeidallah Hichri, Jean-C Laurin, Cécile A. Julien, Vincent Joseph, Aida Bairam

   Pages 43-48

8. Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization

   • Insook Kim, David F. Donnelly, John L. Carroll

   Pages 49-54

9. Erythropoietin and the Sex-Dimorphic Chemoreflex Pathway

   • Jorge Soliz, Hanan Khemiri, Céline Caravagna, Tommy Seaborn

   Pages 55-62

10. Time-Course of Ventilation, Arterial and Pulmonary CO2 Tension During CO2 Increase in Humans

    • Toru Satoh, Yasumasa Okada, Yasushi Hara, Fumio Sakamaki, Shingo Kyotani, Takeshi Tomita et al.

    Pages 63-70

11. Oxygen Sensitive Synaptic Neurotransmission in Anoxia-Tolerant Turtle Cerebrocortex

    • Leslie T. Buck, D. W. R. Hogg, C. Rodgers-Garlick, M. E. Pamenter

    Pages 71-79

12. Ion Channel Regulation by the LKB1-AMPK Signalling Pathway: The Key to Carotid Body Activation by Hypoxia and Metabolic Homeostasis at the Whole Body Level

    • A. Mark Evans, Chris Peers, Christopher N. Wyatt, Prem Kumar, D. Grahame Hardie

    Pages 81-90

13. Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices

    • Araya Ruangkittisakul, Klaus Ballanyi

    Pages 91-98

14. Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells

    • Mieczyslaw Pokorski, Lidia Faff, Camillo Di Giulio

    Pages 99-103

15. Acute Hypoxia Does Not Influence Intracellular pH in Isolated Rat Carotid Body Type I Cells

    • Ryan L. Shapiro, Barbara L. Barr, Robert W. Putnam, Christopher N. Wyatt

    Pages 105-107

16. Hydrogen Sulfide (H2S): A Physiologic Mediator of Carotid Body Response to Hypoxia

    • Nanduri R. Prabhakar

    Pages 109-113

17. The Retrotrapezoid Nucleus and Breathing

    • Patrice G. Guyenet, Ruth L. Stornetta, Stephen B. G. Abbott, Seth D. Depuy, Roy Kanbar

    Pages 115-122

18. The Interaction Between Low Glucose and Hypoxia in the in vitro, Rat Carotid Body

    • Andrew P. S. Holmes, David Hauton, Prem Kumar

    Pages 123-127

19. Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans?

    • Erica A. Wehrwein, Timothy B. Curry, Ananda Basu, Robert A. Rizza, Rita Basu, Michael J. Joyner

    Pages 129-135

20. Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation

    • Patricio Zapata, Carolina Larraín, Edison-Pablo Reyes, Ricardo Fernández

    Pages 137-142

Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.

• Aterial Chemoreceptors
• Carotid Body
• Development
• Neurotransmitters
• Oxygen Sensing

• Dept. Biology, McMaster University, Hamilton, Canada

  Colin A. Nurse

• Facultad de Medicina, Depto. Bioquímica y Biología, Universidad de Valladolid, Valladolid, Spain

  Constancio Gonzalez

• Fac. Medicine & Health, Division of Cardiovascular &, University of Leeds, Leeds, United Kingdom

  Chris Peers

• , Biological Sciences Div &, University of Chicago, Chicago, USA

  Nanduri Prabhakar

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