Anaesthesia, Pain, Intensive Care and Emergency Medicine - A.P.I.C.E.

1. Front Matter

   Pages II-XX

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2. Experimental and Clinical Research in Shock

   1. Front Matter

      Pages 21-21

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   2. Cytokine Activity in Experimental Sepsis

      • H. Zhang

      Pages 23-32

   3. Role of Nitric Oxide in Septic Shock

      • H. Zhang, J. L. Vincent

      Pages 33-47

   4. Novel Approaches to Improve Tissue Oxygen Extraction Capabilities: Lessons Learned from Experimental Septic Shock Models

      • H. Zhang, J. L. Vincent

      Pages 49-56

   5. Should Beta-Blockers Have a Place in the Treatment of Septic Shock?

      • R. Muchada

      Pages 57-65

3. Respiratory Flow Limitation

   1. Front Matter

      Pages 67-67

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   2. Relationship between Chronic Dyspnea and Expiratory Flow Limitation in Patients with COPD

      • N. G. Koulouris, J. Milic-Emili

      Pages 69-74

   3. Pathophysiology of Flow Limitation

      • W. A. Zin

      Pages 75-81

   4. Pharmacological Reversibility of Flow Limitation in COPD and Asthmatic Patients

      • C. Tantucci

      Pages 83-90

   5. Respiratory Muscle Fatigue in COPD Patients

      • T. Vassilakopoulos, S. Zakynthinos, Ch. Roussos

      Pages 91-98

4. Mechanical Ventilation

   1. Front Matter

      Pages 99-99

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   2. Patient-Ventilator Interaction

      • V. M. Ranieri, F. Puntillo, F. Bruno

      Pages 101-109

   3. Spontaneous Breathing Trial with T-Tube

      • F. Gordo, I. Alía, A. Esteban

      Pages 111-116

   4. Continuous Flow Systems

      • R. Brandolese, G. Gritti

      Pages 117-122

   5. Lung Damage by Artificial Ventilation Proof by Radiological Techniques

      • G. A. Wegenius

      Pages 123-131

   6. Barotrauma, Volume Trauma and Their Relation to FRC

      • L. Tremblay, A. S. Slutsky

      Pages 133-139

   7. Iatrogenic Lung Damage by Artificial Ventilation: What Is the Role of the Pulmonary Surfactant System?

      • S. Böhm, G. F. Vazquez de Anda, B. Lachmann

      Pages 141-146

   8. Side Effects of Mechanical Ventilation: Molecular Mechanisms

      • A. N. von Bethmann, S. Uhlig

      Pages 147-154

   9. Physiological Rationale to Prevent Ventilation-Induced Lung Injury

      • B. Lachmann, S. J. C. Verbrugge

      Pages 155-163

The management of critically ill patients has,in the past few years, been a discipline at the forefront of development which continues to make progress with the support of basic and clinical research in the broadest sense. The application of biotechnology in this particular area has revealed itself to be essential in an attempt to provide the best interpretation of the bio-humoral and functional alterations present in a long series of often complex clinical conditions. The care of the critically ill is also at the forefront in the application of increasingly sophisticated clinical monitoring systems that also contribute to standardizing certain procedures, establish guidelines, and evaluate the efficacy of therapeutic interventions and their costs.

• Anaesthesia
• Critical Care
• Failure
• Intensive Care
• Pain
• Trauma
• intensive care medicine

• Department of Anaesthesiology and Intensive Care, Trieste University School of Medicine, Trieste, Italy

  Antonino Gullo

Policies and ethics