Adhesion in Leukocyte Homing and Differentiation

1. Front Matter

   Pages I-IX

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2. The Dominance of Antigern-Specific Receptors in Antigen-Specific Immune Responses

   1. The Dominance of Antigen-Specific Receptors in Antigen-Specific Immune Responses

      • F. Melchers

      Pages 1-3

3. Adhesion Molecules

   1. Front Matter

      Pages 5-5

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   2. Integrins and Their Ligands

      • A. Sonnenberg

      Pages 7-35

   3. Platelet Endothelial Cell Adhesion Molecule (CD31)

      • H. M. DeLisser, P. J. Newman, S. M. Albelda

      Pages 37-45

   4. CD44: A Multitude of Isoforms with Diverse Functions

      • U. Günthert

      Pages 47-63

   5. The Selectins and Their Ligands

      • D. Vestweber

      Pages 65-75

4. Regulation of Leukocyte-Endothelial Cell Adhesion

   1. Front Matter

      Pages 77-77

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   2. A Model of Leukocyte Adhesion to Vascular Endothelium

      • N. Hogg

      Pages 79-86

   3. Regulation of Adhesion Receptors Expression in Endothelial Cells

      • P. Defilippi, L. Silengo, G. Tarone

      Pages 87-98

   4. Regulation of Leukocyte Recruitment by Proadhesive Cytokines Immobilized on Endothelial Proteoglycan

      • Y. Tanaka, D. H. Adams, S. Shaw

      Pages 99-106

5. Lymphoid Cell Homing Mechanisms

   1. Front Matter

      Pages 107-107

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   2. Migration of Activated Lymphocytes

      • A. Hamann, S. Rebstock

      Pages 109-124

   3. The Peyer’s Patch Homing Receptor

      • M. C.-T. Hu, B. Holzmann, D. T. Crowe, H. Neuhaus, I. L. Weissman

      Pages 125-138

   4. Pro-T Cell Homing to the Thymus

      • D. Dunon, P. Ruiz, B. A. Imhof

      Pages 139-150

   5. Quantitative Analysis of Lymphocyte Fluxes In Vivo

      • R. Pabst, R. M. Binns, H. J. Rothkötter, J. Westermann

      Pages 151-159

   6. Lymphocyte Recirculation and Life Span In Vivo

      • A. J. Young, J. B. Hay, C. R. Mackay

      Pages 161-173

6. Leukocyte Homing to Inflamed Tissues

   1. Front Matter

      Pages 175-175

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   2. The Contributions of Integrins to Leukocyte Infiltration in Inflamed Tissues

      • T. B. Issekutz

      Pages 177-185

   3. Regulation of Adhesion and Adhesion Molecules in Endothelium by Transforming Growth Factor-β

      • Y. Khew-Goodall, J. R. Gamble, M. A. Vadas

      Pages 187-199

This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the workshop speakers have contributed to it. Cell adhesion is one of the most dynamic fields of biological research and presented in this book is the current knowledge on the structure and function of the major families of cell adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. Complex interactions between the members of these families mediate diverse adhesion functions, including leukocyte-leukocyte interactions, lymphocyte homing, inflammation, and lymphocyte-stromal cell interaction during hematopoiesis. A great deal of emphasis is placed on the regulatory elements that control the expression and function of adhesion molecules. Cytokines not only induce the expression of certain adhesion molecules, but may also modify their functional status. For instance, the integrins exist in either an inactive nonfunctional form or an active functional form, and a number of intracellular or extracellular stimuli modify integrin function. This is particularly important during leukocyte binding to endothelium and transendothelial migration, which proceeds through a cascade of adhesion events. Although cell adhesion molecules play an important role in many processes, this book concentrates on their role within the immune system. A number of chapters discuss the migration of lymphocytes between hematopoietic organs such as the thymus, lymph nodes, Peyer's patches, and spleen.

• Filtration
• Lymphozyten
• T cell
• Thymus
• antigen
• cell
• cytokine
• growth factor
• immune response
• immune system
• immunoglobulin
• inflammation
• lymphocytes
• migration
• receptor

• Basel Institute for Immunology, Basel, Switzerland

  Dominique Dunon, Charles R. Mackay, Beat A. Imhof

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