Overview
- Offers a comprehensive review of locoregional radionuclide cancer therapies (LRCT)
- Includes updated scientific modeling and imaging algorithms
- Written by experts
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (11 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.
Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.
This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Editors and Affiliations
About the editor
Franklin C. L. Wong
University of Texas
MD Anderson Cancer Center
Houston, TX
USA
Bibliographic Information
Book Title: Locoregional Radionuclide Cancer Therapy
Book Subtitle: Clinical and Scientific Aspects
Editors: Franklin C.L. Wong
DOI: https://doi.org/10.1007/978-3-030-56267-0
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-56266-3Published: 09 December 2020
Softcover ISBN: 978-3-030-56269-4Published: 10 December 2021
eBook ISBN: 978-3-030-56267-0Published: 08 December 2020
Edition Number: 1
Number of Pages: XII, 268
Number of Illustrations: 20 b/w illustrations, 56 illustrations in colour
Topics: Nuclear Medicine, Imaging / Radiology, Internal Medicine