Hypertension in Children and Adolescents

1. Front Matter

   Pages i-viii

   PDF

2. From Pregnancy to Childhood and Adulthood: The Trajectory of Hypertension

   • Manish D. Sinha

   Pages 1-16

3. The Contributions of Perinatal Programming to Blood Pressure Levels in Childhood and Beyond

   • Julie R. Ingelfinger

   Pages 17-30

4. Worldwide Prevalence of Childhood Hypertension

   • Bonita Falkner

   Pages 31-40

5. Office and Out of Office Blood Pressure Measurements

   • Stella Stabouli

   Pages 41-64

6. Large Vessels in Hypertension: Central Blood Pressure

   • Stéphane Laurent, Pedro Guimarães Cunha

   Pages 65-83

7. Isolated Systolic Hypertension in the Young

   • Empar Lurbe

   Pages 85-93

8. Primary Hypertension

   • Janusz Feber, Mieczysław Litwin

   Pages 95-110

9. Causes of Secondary Hypertension in Children and Adolescents

   • Rowena Lalji, Kjell Tullus

   Pages 111-130

10. Monogenic Hypertension

    • Mieczysław Litwin, Janusz Feber, Elżbieta Ciara

    Pages 131-153

11. Neonatal Hypertension

    • Joseph T. Flynn

    Pages 155-176

12. The Heart in Childhood Hypertension

    • Asle Hirth

    Pages 177-189

13. The Kidney in Hypertension

    • Elke Wühl, Franz Schaefer

    Pages 191-210

14. Non-pharmacological Treatment of Hypertension

    • Dénes Páll, Miklós Zrínyi

    Pages 211-224

15. Physical Exercise in the Treatment of Obesity and Hypertension: New Approach to Individualize Treatment

    • Pau Redon

    Pages 225-238

16. Treatment of Hypertension in Chronic Kidney Disease

    • Elke Wühl, Franz Schaefer

    Pages 239-255

17. Long Term Follow-Up

    • Tomáš Seeman

    Pages 257-262

18. Evidences from Clinical Trials and Use of Antihypertensive Drugs in Children and Adolescents

    • Josep Redon, Pau Redon

    Pages 263-277

This book is devoted to hypertension in children and adolescents, a clinical issue that – thanks to the strides made in several areas of pathophysiological and clinical research – has received growing interest in cardiovascular medicine over the last several years.

Given the increasing prevalence of hypertension in children and adolescents, this book represents an important and useful tool to address what has become a significant public health issue. It covers a diverse range of topics, from advances in the definition of hypertension and the identification of new risk factors, to current treatment strategies.

The book also presents an overview of the latest findings, including the clinical significance of isolated systolic hypertension (ISH) in youth, the importance of out-of-office and central blood pressure measurement, new methods for assessing vascular phenotypes, and clustering of CV risk factors.

Gathering contributions by international experts and pursuing a practice-oriented approach, the book offers a valuable tool for cardiologists, pediatricians and nephrologists, as well as general practitioners.

• isolated systolic hypertension
• hypertension treatment
• early origins of cardiometabolic disease
• therapeutic trials
• Perinatal programing and blood pressure
• Central blood pressure
• Monogenic hypertension
• Neonatal hypertension

• Head of Pediatrics Department, Hospital General Universitario Valencia, Spain

  Empar Lurbe

• Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  Elke Wühl

Empar Lurbe, MD, pHD, graduated from the Medical College of Valencia in 1976. She subsequently trained in pediatrics at the Hospital La Fe in Valencia. She completed her pediatric nephrology and hypertension fellowship at Northwestern University in Chicago, Illinois, in 1992.
In addition to practicing clinical pediatric nephrology at Valencia, she is also Head of the Pediatric Department and the Pediatric Unit against Obesity and Cardiovascular Risk in Children and Adolescents. Her research interests have led her to focus on epidemiologic studies of CV risk factors in children. She initiated the 24-hour ambulatory blood pressure and supervised collection of CV data for over two decades.
Dr. Lurbe is a Full Professor at Valencia University and became Head of Group at CIBERobn, Instituto de Salud Carlos III in 2006. This new opportunity allowed her to concentrate her clinical practice on the diagnosis and treatment of high blood pressure and obesity. She has since continued her research, focusing on non-invasive methods for measuring atherosclerosis, especially vascular function abnormalities, using Carotid Ultrasound, Arterial Stiffness and Endothelial Function. Her current research includes the application of 24- hour ambulatory blood pressure central BP and these new techniques to study the roles that pre- and post-natal nutrition, obesity, high blood pressure, cholesterol and diabetes play in the development of hardening of the arteries.

Dr. Elke Wühl is Professor of Pediatrics and consultant pediatric nephrologist at the Center of Pediatric and Adolescent Medicine, University of Heidelberg, Germany.

She received her doctorate (Dr. med.) from Heidelberg University Medical School and completed her residency and pediatric nephrology training at the University Children’s Hospital Heidelberg. She is certified pediatric nephrologist and hypertension specialist (DHL).

Dr. Wühl has special interest in progression of chronic kidney disease and associated cardiovascular comorbidities and is involved in several clinical intervention trials in the pediatric chronic kidney disease population. Her research interests include pediatric hypertension, blood pressure rhythmicity, and cardiovascular morphology and function. Her publication list includes publications on reference data for ambulatory blood pressure monitoring, carotid intima media thickness, and pulse wave velocity. She is a member of national and international pediatric hypertension guideline committees.

Policies and ethics