Editors:
- Focuses specifically on the role of CSCs in solid cancers
- Written by active investigators with research programs related to oncology and/or stem cell biology and leaders in their field
- Provides a comprehensive overview of this evolving and important field
- Includes supplementary material: sn.pub/extras
Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (24 chapters)
-
Front Matter
-
Introduction to Cancer Stem Cells
-
Front Matter
-
-
FORWARD AND INTRODUCTION TO CANCER STEM CELLS
-
Cancer Stem Cells in Solid Tumors
-
Front Matter
-
-
CANCER STEM CELLS IN SOLID TUMORS
-
Cancer Stem Cell Gene Expression and Mechanisms: Convergence of Embryonic and Tumorigenic Signaling Pathways
-
Front Matter
-
-
CANCER STEM CELL GENE EXPRESSION AND MECHANISMS:CONVERGENCE OF EMBRYONIC AND TUMORIGENIC SIGNALING PATHWAYS
-
Model Systems for Studying Cancer Stem Cell Biology and Therapeutic Development
-
Front Matter
-
-
MODEL SYSTEMS FOR STUDYING CANCER STEM CELL BIOLOGY AND THERAPEUTIC DEVELOPMENT
About this book
The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs.
Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.
Topics covered include:
- Introduction of the CSC hypothesis
- Historical perspectives and the contributing lessons from leukemia
- Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer
- Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs
- The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance
- Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field
This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.
Reviews
From the reviews:
“The book is written for established researchers, professors, healthcare professionals, and students in the medical and scientific community. … This is a well-written, well-structured book that covers a recently emerging and highly important area of cancer research, and consequently provides readers with important new information on cutting-edge biomedical research aimed at understanding the cellular and molecular underpinnings of solid tumor development.” (Steven Rosen, Doody’s Book Reviews, February, 2012)Editors and Affiliations
-
Dept. Oncology & Anatomy & Cell Biology, University of Western Ontario, London, Canada
Alison L. Allan
Bibliographic Information
Book Title: Cancer Stem Cells in Solid Tumors
Editors: Alison L. Allan
Series Title: Stem Cell Biology and Regenerative Medicine
DOI: https://doi.org/10.1007/978-1-61779-246-5
Publisher: Humana Totowa, NJ
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-61779-245-8Published: 12 August 2011
Softcover ISBN: 978-1-61779-758-3Published: 24 October 2013
eBook ISBN: 978-1-61779-246-5Published: 12 August 2011
Series ISSN: 2196-8985
Series E-ISSN: 2196-8993
Edition Number: 1
Number of Pages: XVIII, 478
Topics: Stem Cells, Cell Biology, Cancer Research