Med-X - Call for Papers Med-X Special Issue: Live Cell Imaging and Manipulation

Introduction: Fluorescent proteins allow live cell visualization with high spatiotemporal resolutions, which advances our in-depth understanding of life science. Protein engineering has also led to numerous tools for the control of cellular functions. This special issue focuses on the technologies of live cell imaging and manipulation in the field of biology and bioengineering. It covers the use of genetically encodable fluorescent biosensors that allow for the visualization of molecular activities and interactions in live cells, and the integration with chemical and physical approaches for signaling manipulation. The articles in the special issue discuss the development of different imaging tools such as fluorescence resonance energy transfer (FRET), split fluorescent proteins, CRISPR/dCas9-based fluorescence labeling, circularly permuted fluorescent proteins (CPFP), and other fluorescent protein-based imaging techniques for monitoring dynamic molecular events in single cell. Meanwhile, the articles also discuss the chemical/physical approaches such as chemical inducible dimerization system, light-inducible system, ultrasound-inducible system and other inducible techniques for genetic and epigenetic manipulation. The authors highlight the advantages of current live cell imaging technologies, including increased dynamic range, higher sensitivity and specificity, and improved signal-to-noise ratio. The special issue also highlights the potential of visible manipulation in understanding the molecular and cellular function and in developing novel therapeutic approaches. In conclusion, this special issue provides an overview of the latest advances in the field of live cell imaging and manipulation in biology and bioengineering. It highlights the potential of these imaging and manipulation techniques in improving the accuracy of the measurement of kinase activities, genetic and epigenetic activities, ultimately leading to better understanding of the fundamental mechanisms and targets for therapeutics.

Leading Editor:

Yingxiao Wang, Ph.D., Professor

Affiliation: University of Southern California

Guest Editor：

Qin Peng, Ph.D., Distinguished Researcher

Affiliation: Shenzhen Bay Laboratory

Submission deadline: 4/30/2024