1. Statistics in Therapeutic Innovation and Regulatory Decision Making

   • J. Rick Turner

   Commentary 30 December 2014 Pages: 9 - 9

2. The Role of Statistics in Regulatory Decision Making

   • Lisa M. LaVange

   Special Issue on Statistics 30 December 2014 Pages: 10 - 19

3. Adaptive Clinical Trials

   • Olga Marchenko
   • Valerii Fedorov
   • José Pinheiro

   Special Issue on Statistics 30 December 2014 Pages: 20 - 30

4. Adaptive Clinical Trials: Overview of Phase III Designs and Challenges

   • Jeff Maca
   • Vladimir Dragalin
   • Paul Gallo

   Special Issue on Statistics 30 December 2014 Pages: 31 - 40

5. Adaptive Design Applied to Identification of the Minimum Effective Dose in Schizophrenia

   • Tom Parke
   • Vladimir Dragalin
   • ISCTM Adaptive Design Working Group

   Special Issue on Statistics 30 December 2014 Pages: 41 - 50

6. A Conditional Adaptive Weighted Test Method for Confirmatory Trials

   • Sue-Jane Wang
   • H. M. James Hung

   Special Issue on Statistics 30 December 2014 Pages: 51 - 55

7. Dose-Response Determination in Multistage Endpoint Clinical Trials

   • Fei Chen
   • José Pinheiro

   Special Issue on Statistics 30 December 2014 Pages: 56 - 61

8. Remaining Challenges in Assessing Non-Inferiority

   • Steven Snapinn
   • Qi Jiang

   Special Issue on Statistics 30 December 2014 Pages: 62 - 67

9. Recent Developments in the Prevention and Treatment of Missing Data

   • C. Mallinckrodt
   • J. Roger
   • P. Bunouf

   Special Issue on Statistics 30 December 2014 Pages: 68 - 80

10. Advances in Statistical Approaches to Oncology Drug Development

    • Anastasia Ivanova
    • Gary L. Rosner
    • Yanping Wang

    Special Issue on Statistics 30 December 2014 Pages: 81 - 89

11. Recent Statistical Contributions to Medical Device Development

    • Brian L. Wiens
    • Theodore C. Lystig
    • Scott M. Berry

    Special Issue on Statistics 30 December 2014 Pages: 90 - 97

12. A Review of Statistical Methods for Safety Surveillance

    • Lan Huang
    • Ted Guo
    • Ram C. Tiwari

    Special Issue on Statistics 30 December 2014 Pages: 98 - 108

13. Statistical Evaluation of Drug Safety Data

    • H. Amy Xia
    • Qi Jiang

    Special Issue on Statistics 30 December 2014 Pages: 109 - 120